People, Technologies and data sources behind HaploFind.
Haplofind is based on PhyloTree(1), the Human Phylogenetic tree mainteined by Van Oven (HaploFind is regularly updated following PhyloTree releases and always uses the last available version, currently version 17).
Mitochondrial gene locus and disease associations data are obtained from MitoMap(2) Database (Disease associations are updated together with PhyloTree updates).
Alignment and SNP Discovery capabilities are provided by Mummer.(3)
Sequences used to weight our tree are regularly downloaded from GenBank.
HaploFind was developed and is actively maintained by the Laboratory of Immunology - Department of Experimental, Diagnostic and Specialty Medicine - University of Bologna.
(1) van Oven M, Kayser M. 2009. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30(2):E386-E394. http://www.phylotree.org. doi:10.1002/humu.20921
(2) MITOMAP: A Human Mitochondrial Genome Database. http://www.mitomap.org, 2011.
(3) "Versatile and open software for comparing large genomes." S. Kurtz, A. Phillippy, A.L. Delcher, M. Smoot, M. Shumway, C. Antonescu, and S.L. Salzberg, Genome Biology (2004), 5:R12.